| Date | Location | Score | Winner |
|---|---|---|---|
| June Series — Wrigley Field | |||
| June 11 | Wrigley Field | Sox 10–5 | White Sox W: Peavy (5-5) L: Wells (3-5). Peavy dominates: 7 IP, 6 H, 5 K. AJ goes 4-for-4 with HR, double, 3 RBI. Rios hits his 13th. Sox win their 4th straight in the series. Soriano answers with his 10th HR. |
| June 12 | Wrigley Field | Sox 2–1 | White Sox W: Buehrle (4-6) L: Silva (8-1) SV: Jenks (11). Cubs go 1-for-10 with RISP. Konerko 3-for-4 with 2 RBI. Buehrle pitches out of jams twice. Sox win their 5th straight vs. Cubs dating back to 2009. |
| June 13 | Wrigley Field | Cubs 1–0 | Cubs W: Lilly (2-5) L: Floyd (2-7) SV: Marmol (13). Floyd throws 6 no-hit innings. Lilly takes a no-hitter into the 9th — Juan Pierre breaks it up with a pinch-hit single. Marmol then walks the bases loaded, balks twice, intentional walk to Rios, gets Konerko on a force at home and Quentin on a pop-up. Cubs win 1-0 on a Soriano double and Tracy RBI single in the 7th. Historic: the only MLB game other than Reds/Cubs May 2, 1917 with double no-hitters through 9 innings. |
| June Series — U.S. Cellular Field | |||
| June 25 | U.S. Cellular Field | Sox 6–0 | White Sox W: Peavy (7-5) L: Zambrano. Peavy: 7 IP, 3 H, 9 K. Quentin 3-run HR in the 1st. Juan Pierre doubles to lead off — Zambrano screams at Derrek Lee in the dugout, gets restrained by Soto, sent home, and suspended indefinitely. Tom Gorzelanny replaces him. The Gatorade cooler was unavailable for comment. |
| June 26 | U.S. Cellular Field | Sox 3–2 | White Sox W: Putz (4-2) L: Cashner (0-1) SV: Thornton (3). Konerko hits his 19th HR off Cashner in the 8th for the walk-off. Ramirez returns from DL and hits his 6th. Sox win their 10th straight vs. the Cubs. |
| June 27 | U.S. Cellular Field | Cubs 8–6 | Cubs W: Dempster (6-6) L: Danks (7-6). Konerko hits HR #20 all-time in the Crosstown Classic. Tyler Colvin 3-run HR, 4 RBI. Cubs halt the Sox 11-game winning streak. Marmol escapes the 9th with a 2-run Sox threat. |
2010 was the first year of the BP Crosstown Cup — an actual trophy awarded to the team winning the season series, with a tiebreaker going to whoever won the last game. The Sox took it home in year one.
The Wrigley series had the game of the year on June 13: Gavin Floyd threw 6 no-hit innings for the Sox. Ted Lilly threw 6 no-hit innings for the Cubs. Floyd gave up his first hit in the 7th to Soriano, and Chad Tracy drove him in for the only run of the game. Lilly then took his no-hitter into the 9th — Juan Pierre pinch-hit and singled to break it up. Carlos Marmol came in, walked the bases loaded, balked twice, walked Rios intentionally, and then got Konerko on a force at home and Quentin on a pop fly. Cubs 1-0. Only the second game in MLB history with double no-hitters through 9 innings — the other was Reds at Cubs, May 2, 1917.
Then June 25 at U.S. Cellular: Carlos Zambrano started, Juan Pierre doubled to lead off, and something set Big Z off. He went into the dugout screaming at Derrek Lee. Geovany Soto had to physically restrain him. Lou Piniella sent him home. Jim Hendry suspended him indefinitely. Peavy threw 7 innings and struck out 9. Sox win 6-0. The Gatorade cooler was unavailable for comment, but reportedly felt safer than usual.
The Sox won 10 straight against the Cubs before the Cubs finally stopped it on June 27, 8-6, with Tyler Colvin going 3-for-5 with a 3-run HR and 4 RBI. Konerko hit his 20th career Crosstown Classic HR in that game — the all-time record. After 2010: Sox 41, Cubs 37.